Objective: To analyze the situation and common problems discovered between 2018 and 2019 during the follow-up inspections of drug wholesale enterprises of Guangdong Province as the new Good Supply Practice (GSP) was implemented with the aim to provide references for making regulatory measures and avoiding similar problems. Methods: The defective items found during the follow-up inspections of 122 drug wholesale enterprises were analyzed. The main problems and possible causes in quality management system of the drug wholesale enterprises were also analyzed and the corresponding countermeasures were put forward. Results and Conclusion: In the GSP follow-up inspections of 122 drug wholesale enterprises, a total of 141 items, equal to 488 defective items were found, which were mainly distributed in five aspects, including drug storage and maintenance(18.03%), facilities and equipment(14.75%), personnel and training(13.93%), institutional and quality management responsibilities(7.58%), as well as quality management system(7.17%). The drug wholesale enterprises should improve the pertinence and effectiveness of the training, enhance quality management system internal verification, give full play to the role of the quality management department in all aspects and continuously improve and perfect quality management system.