Objective: To establish a method for the content determination of palladium catalyst residue in vortioxetine hydrobromide. Methods: Graphite furnace atomic absorption spectrometry method was used to determine the palladium residue content in vortioxetine hydrobromide. Test conditions were as follows:the palladium hollow cathode lamp was used as the light source, the detection wavelength was 247.6 nm, the slit was 0.4 nm, and the lamp current was 2 mA with transverse heating graphite tube. The programmed heating was used for graphite furnace. Results: It showed a good linear relationship within the concentration range of 0-80 μg·L-1 (r=0.9995). The detection limit and the characteristic concentration were 0.59 μg·L-1 and 1.96 μg·L-1, respectively. The average recovery was 102.1% with RSD of 3.24% (n=9). Conclusion: This method could be used for the determination of the trace palladium content in vortioxetine hydrobromide after methodology verification, and could provide references for the establishment of quality standard of raw material medicine.
Zhang Hui, Wang Zhihua, Xie Xiaodong, Huang Baohong, Li Minghua, Li Jianwei, Qiao Yufeng
. Establishment of a Method for Monitoring the Catalyst Palladium Residual Content in Vortioxetine Hydrobromide Bulk Drug[J]. Chinese Pharmaceutical Affairs, 2017
, 31(1)
: 69
-73
.
DOI: 10.16153/j.1002-7777.2016.11.013
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