Production Management

Changes of Antibacterial Active Substances in Cephalosporin C Fermentation Residues after Treatments with Different Harmless and Resource-based Technologies

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  • National Institutes for Food and Drug Control, Beijing 100050, China

Online published: 2018-08-28

Abstract

Objective:To establish a method to effectively evaluate the harmless treatment effect of antibiotic fermentation residues. Methods:Sensitive strains were used to screen the antibacterial activity of harmlesstreated fermentation residues. The structures of residual or transformed components were inferred by HPLCMS. The biological and safety information of these components were retrieved in relevant compound public databases. Results:The untreated Cephalosporin C fermentation residues contained β-lactamase active substances among the 4 cephalosporin C residues that are tested. Among the three kinds of fermentation residues treated by harmless treatments, only one kind no longer had antibacterial activities, the other 2 kinds which were treated by composting together with city waste of sludge contained non β-lactamase active substances that were different from the activity of untreated residues. Conclusion:The effect of harmless treatment can be evaluated by specific residual antibiotics in the residues. Moreover, the bioconversion of residual substances in the composting process should also be considered.

Cite this article

Chang Yan, Zhang Xia, Li Jin, Hu Changqin . Changes of Antibacterial Active Substances in Cephalosporin C Fermentation Residues after Treatments with Different Harmless and Resource-based Technologies[J]. Chinese Pharmaceutical Affairs, 2018 , 32(8) : 1088 -1096 . DOI: 10.16153/j.1002-7777.2018.08.013

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