Objective:To analytically characterize the structure of pharmaceutical excipient Dimethicone. Methods:UHPLC-HRMS detection was used to analyze the structure of Dimethicone based on molecular ion peak and fragment information provided by high resolution mass spectrometry. Samples of Dimethicone 20, 50, 100, 200, 350, 500, 750, 1000, 12500 and 30000 series numbers were analyzed and characterized by using the data analysis functions of MassHunter mass spectrometer. Results:Dimethicone could be classified into different types according to its viscosity. With the increase of the models, the viscosity increases continuously. There was phenomenon of molecular crosslinking in the structure of Dimethicone according to the analysis of the molecular structure of dimethicone. And the proportion of molecular crosslinking was positively correlated with its viscosity. Conclusion:The viscosity of Dimethicone is an important functionality-related characteristic. The viscosity of Dimethicone is related not only to its degree of polymerization, but also to the proportion of molecule crosslinking.
Yang Rui, Wang Lulu, Zhao Xin, Xu Kai, Li Hailiang, Wang Jue, Zhang Zhaoyang, Sun Huimin
. On Characterization of Molecular Cross-linking of Dimethicone[J]. Chinese Pharmaceutical Affairs, 2019
, 33(7)
: 774
-782
.
DOI: 10.16153/j.1002-7777.2019.07.009
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