[1] Gordon L Amidon,Hans Lennern?s,Vinod P Shah,et al.A Theoretical Basis for a Biopharmaceutic Drug Classification:The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability[J].Pharmaceutical Research,1995,12(3):413-420.
[2] Julia DR Schulze,Diane AI Ashiru,Mandeep K Khela,et al.Impact of Formulation Excipients on Human Intestinal Transit[J].Journal of Pharmacy and Pharmacology,2006,58(6):821-825.
[3] Dawn A Adkin,Stanley S Davis,Robert A Sparrow,et al.The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit:Implications for Drug Absorption[J].Pharmaceutical Research,1995,12(3):393-396.
[4] Wael Gamal,Rania H Fahmy,Magdy I Mohamed.Development of Novel Amisulpride-loaded Liquid Selfnanoemulsifying Drug Delivery Systems via Dual Tackling of Its Solubility and Intestinal Permeability[J].Drug Development and Industrial Pharmacy,2017,43(9):1530-1538.
[5] Ahmed A Abdulhussein Al-Ali,Bente Steffansen,René Holm,et al.Nonionic Surfactants Increase Digoxin Absorption in Caco-2 and MDCKII MDR1 Cells:Impact on P-glycoprotein Inhibition,Barrier Function,andRepeated Cellular Exposure[J].International Journal ofPharmaceutics,2018,551(1/2):270-280.
[6] Avital Beig,Noa Fine-Shamir,Daniel Porat,et al.Concomitant Solubility-permeability Increase:Vitamin E TPGS vs.Amorphous Solid Dispersion as Oral Delivery Systems for Etoposide[J].European Journal of Pharmaceutics and Biopharmaceutics,2017(121):97-103.
[7] Bhagwant D Rege,Lawrence X Yu,Ajaz S Hussain,et al.Effect of Common Excipients on Caco-2 Transport of Low‐permeability Drugs[J].Journal of Pharmaceutical Sciences,2001,90(11):1776-1786.
[8] Mai Yang,Murdan Sudaxshina,Awadi Marwa,et al.Establishing an In Vitro Permeation Model to Predict the In Vivo Sex-related in Fluence of PEG 400 on Oral Drug Absorption[J].International Journal of Pharmaceutics,2018,542(1-2):280-287.
[9] Schulze JD,Waddington WA,Eli PJ,et al.Concentrationdependent Effects of Polyethylene Glycol 400 on Gastrointestinal Transit and Drug Absorption[J].Pharmaceutical Research,2003,20(12):1984-1988.
[10] Chen ML,Straughn AB,Sadrieh N,et al.A Modern View of Excipient Effects on Bioequivalence:Case Study of Sorbitol.[J].Pharmaceutical Research,2007,24(1):73-80.
[11] Ranjeet Prasad Dash,Nuggehally R Srinivas,R Jayachandra Babu.Use of Sorbitol as Pharmaceutical Excipient in the Present Day Formulations-issues and Challenges for Drug Absorption and Bioavailability[J].Drug Development and Industrial Pharmacy,2019,45(7/12):1421-1429.
[12] Mei-Ling Chen,Nakissa Sadrieh,Lawrence Yu.Impact of Osmotically Active Excipients on Bioavailability and Bioequivalence of BCS Class Ⅲ Drugs[J].The AAPS Journal,2013,15(4):1043-50.
[13] Iida Aiko,Tomita Mikio,Idota Yoko,et al.Improvement of Intestinal Absorption of P-glycoprotein Substrate b y D-t a r t a r i c A c i d [J].D r u g M e t a b o l i s m a n d Pharmacokinetics,2006,21(5):424-8.
[14] 郭荔.药用辅料Pluronic F68和Labrasol对4种药物渗透性和P-糖蛋白外排功能的影响[D].南京:南京农业大学,2019.
[15] Avital Beig,Noa Fine-Shamir,Daniel Porat,et al.Concomitant Solubility-permeability Increase:Vitamin E TPGS vs.Amorphous Solid Dispersion as Oral Delivery Systems for Etoposide[J].European Journal of Pharmaceutics and Biopharmaceutics,2017(121):97-103.
[16] Takizawa Yusuke,Goto Nozomi,Furuya Takahito,et al.Influene of Pharmaceutical Excipients on the Membrane Transport of a P-glycoprotein Substrate in the Rat Small Intestine[J].European Journal of Drug Metabolism and Pharmacokinetics,2020,45(5):645-652.
[17] Gurjar,Rohan,Chan,et al.Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro[J].Molecular Pharmaceutics,2018,15(11):4835-4842.
[18] Chaudhary Nandini,Tripathi Devika,Rai Awani K.A Technical Approach of Solubility Enhancement of Poorly Soluble Drugs:Liquisolid Technique[J].Current Drug Delivery,2020,17(8):638-650.
[19] Khames Ahmed.Investigation of the Effect of Solubility Increase at the Main Absorption Site on Bioavailability of BCS Class II Drug(risperidone)Using Liquisolid Technique[J].Drug delivery,2017,24(1):328-338.
[20] Roger Vandecruys,Jef Peeters,Geert Verreck,et al.Use of a Screening Method to Determine Excipients which Optimize the Extent and Stability of Supersaturated Drug Solutions and Application of this System to Solid Formulation Design[J].International Journal of Pharmaceutics,2007,342(1):168-175.
[21] Brewster M E,Vandecruys R,Verreck G,et al.Supersaturating Drug Delivery Systems:Effect of Hydrophilic Cyclodextrins and Other Excipients on the Formation and Stabilization of Supersaturated Drug Solutions[J].Die Pharmazie,2008,63(3):217-220.
[22] Zheng Lu,Yonglai Yang,Rae-Ann Covington,et al.Supersaturated Controlled Release Matrix Using Amorphous Dispersions of Glipizide[J].International Journal of Pharmaceutics,2016,511(2):957-968.
[23] Wang Shan,Liu Chengyu,Chen Yuejie,et al.Aggregation of Hydroxypropyl Methylcellulose Acetate Succinate under Its Dissolving pH and the Impact on Drug Supersaturation[J].Molecular Pharmaceutics,2018,15(10):4643-4653.
[24] Lee Dae Ro,Ho Myoung Jin,Jung Hyuck Jun,et al.Enhanced Dissolution and Oral Absorption of Tacrolimusby Supersaturable Self-emulsifying Drug Delivery System[J].International Journal of Nanomedicine,2016(11):1109-1117.
[25] Dai Wei-Guo,Dong Liang C,Li Shu,et al.Combination of Pluronic/Vitamin E TPGS as a Potential Inhibitor of Drug Precipitation[J].International Journal of Pharmaceutics,2008,355(1-2):31-37.
[26] Dias M MR,Raghavan SL,Pellett MA,et al.The Effect of Beta-cyclodextrins on the Permeation of Diclofenac from Supersaturated Solutions[J].International Journal of Pharmaceutics,2003,263(1-2):173-181.
[27] Sugita M,Kataoka M,Sugihara M,et al.Effect of Excipients on the Particle Size of Precipitated Pioglitazone in the Gastrointestinal Tract:Impact on Bioequivalence[J].Aaps Journal,2014,16(5):1119-1127.
[28] Mariana Colombo,Gabriela de Lima Melchiades,Luana Roberta Michels,et al.Solid Dispersion of Kaempferol:Formulation Development,Characterization,and Oral Bioavailability Assessment[J].AAPS PharmSciTech,2019,20(3):106.
[29] Shah Nirmal,Seth Avinashkumar,Balaraman R,et al.Oral Bioavailability Enhancement of Raloxifene by Developing Microemulsion Using D-optimal Mixture Design:Optimization and In-vivo Pharmacokinetic Study[J].Drug Development and Industrial Pharmacy,2018,44(4):687-696.
[30] Yanhua Liu,Tong Yang,Shijie Wei,et al.Mucus Adhesionand Penetration-enhanced Liposomes for Paclitaxel Oral Delivery[J].International Journal of Pharmaceutics,2018,537(1-2):245-256.
[31] Manuela Natoli,Bruno D Leoni,Igea D Agnano,et al.Good Caco-2 Cell Culture Practices[J].Toxicology in Vitro,2012,26(8):1243-1246.
[32] Janneke Keemink,Christel AS Bergstr?m.Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations[J].Pharmaceutical Research,2018,35(4):74.
[33] Mitali H Patel,Krutika K Sawant.Self Microemulsifying Drug Delivery System of Lurasidone Hydrochloride for Enhanced Oral Bioavailability by Lymphatic Targeting:in Vitro,Caco-2 Cell Line and in Vivo Evaluation[J].European Journal of Pharmaceutical Sciences,2019(138):105027.
[34] Jin Xiannu,Luong Thu-Lan,Reese Necole,et al.Comparison of MDCK-MDR1 and Caco-2 Cell Based Permeability Assays for Anti-malarial Drug Screening and Drug Investigations[J].Journal of Pharmacological and Toxicological Methods,2014,70(2):188-94.
[35] 齐云,王敏,蔡润兰.Caco-2细胞模型在口服药物转运机制研究中应用的进展[J].中国药学杂志,2009,44(17):1281-1284.
[36] Rege BD,Yu LX,Hussain AS,et al.Effect of Common Excipients on Caco-2 Transport of Low-permeability Drugs[J].Journal of Pharmaceutical Sciences,2001,90(11):1776-1786.
[37] Sánchez Aroha B,Calpena Ana C,Mallandrich Mireia,et al.Validation of an Ex Vivo Permeation Method for the Intestinal Permeability of Different BCS Drugs and Its Correlation with Caco-2 in Vitro Experiments[J].Pharmaceutics,2019,11(12):638.
[38] Jong Bong Lee,Atheer Zgair,Dhiaa A Taha,et al.Quantitative Analysis of Lab-to-lab Variability in Caco-2 Permeability Assays[J].European Journal of Pharmaceutics and Biopharmaceutics,2017(114):11438-42.
[39] Song Nai-Ning,Li Quan-Sheng,Liu Chang-Xiao.Intestinal Permeability of Metformin Using Single-pass Intestinal Perfusion in Rats[J].World Journal of Gastroenterology,2006,12(25):4064-70.
[40] Lozoya-Agullo Isabel,Zur Moran,Fine-Shamir Noa,et al.Investigating Drug Absorption from the Colon:Single-pass vs.Doluisio Approaches to In-situ Rat Large-intestinal Perfusion[J].International Journal of Pharmaceutics,2017,527(1-2):135-141.
[41] Cassiana Mendes,Gabriela C Meirelles,Marcos AS Silva,et al.Intestinal Permeability Determinants of Norfloxacin in Using Chamber Model[J].European Journal of Pharmaceutical Sciences,2018(121):236-242.
[42] Amruta Tambe,Priyankai Mokashi,Nancy Pandita.Ex-vivo Intestinal Absorption Study of Boswellic Acid,Cyclodextrin Complexes and Poloxamer Solid Dispersions Using Everted Gut Sac Technique[J].Journal of Pharmaceutical and Biomedical Analysis,2019(167):66-73.
[43] Cornaire G,Woodley JF,Saivin S,et al.Effect of Polyoxyl 35Castor Oil and Polysorbate 80 on the Intestinal Absorptionof Digoxin in Vitro[J].Arzneimittelforschung,2000,50(6):576-579.
[44] Kansy M,Senner F,Gubernator K.Physicochemical High Throughput Screening:Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes[J].Journal of Medicinal Chemistry,1998,41(7):1007-1010.
[45] Alex Avdeef.Absorption and Drug Development Second Edition[M].Wiley,2012:336-345.
[46] Avdeef A.The Rise of PAMPA[J].Expert Opin Drug Metab Toxicol,2005,1(2):325-42.
[47] Bendels S,Tsinman O,Wagner B,et al.PAMPA–Excipient Classification Gradient Map[J].Pharmaceutical Research,2006,23(11):2525.
[48] Cristoph Wandel,Richard B Kim,C Michael Stein.“Inactive”Excipients Such as Cremophor Can Affect In Vivo Drug Disposition[J].Clinical Pharmacology & Therapeutics,2003,73(5):394-396.